The Emergence of the 16S rRNA Methyltransferase RmtB in a Multidrug-Resistant Serratia marcescens Isolate in China
نویسندگان
چکیده
Xue-Jiao Ma, M.D.*, Hai-Fei Yang, M.D.*, Yan-Yan Liu, M.D., Qing Mei, M.D., Ying Ye, M.D., Hong-Ru Li, M.D., Jun Cheng, M.D., and Jia-Bin Li, M.D. Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei; Institute of Bacterium Resistance, Anhui Medical University, Hefei; Anhui Center for Surveillance of Bacterial Resistance, Hefei; Department of Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha; Department of Infectious Diseases, Chaohu Hospital of Anhui Medical University, Hefei, China
منابع مشابه
Plasmid-mediated 16S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides.
Serratia marcescens S-95, which displayed an unusually high degree of resistance to aminoglycosides, including kanamycins and gentamicins, was isolated in 2002 from a patient in Japan. The resistance was mediated by a large plasmid which was nonconjugative but transferable to an Escherichia coli recipient by transformation. The gene responsible for the aminoglycoside resistance was cloned and s...
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The distribution of conjugative-plasmid-mediated 16S rRNA methylase genes among amikacin-resistant Enterobacteriaceae collected between 1995 and 1998 and between 2001 and 2006 at a university hospital in South Korea was examined, and conjugative plasmids carrying the 16S rRNA methylase genes were characterized by PCR-based replicon typing and by determination of their antimicrobial resistance p...
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OBJECTIVES To investigate the occurrence of 16S rRNA methylases conferring high-level resistance to aminoglycosides in Enterobacteriaceae isolated from two pig farms in China. METHODS Enterobacteriaceae isolated from 151 pig rectal swab samples and 9 environmental samples were screened for the presence of the rmtA, rmtB, armA and rmtC genes by PCR and sequencing. Conjugation experiments were ...
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16S rRNA methylase and QepA, a fluoroquinolone efflux pump, are new mechanisms of resistance against aminoglycosides and fluoroquinolone, respectively. One of 16S rRNA methylase genes, rmtB, was found to be associated with qepA, were both located on the same transposable element. In this study, we intended to determine the current prevalence and characteristics of the 16S rRNA methylase genes a...
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عنوان ژورنال:
دوره 35 شماره
صفحات -
تاریخ انتشار 2015